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- *******************************************************
- * Delta 1-pyrroline-5-carboxylate reductase signature *
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-
- Delta 1-pyrroline-5-carboxylate reductase (P5CR) (EC 1.5.1.2) [1,2] is the
- enzyme that catalyzes the terminal step in the biosynthesis of proline from
- glutamate, the NAD(P) dependent oxidation of 1-pyrroline-5-carboxylate into
- proline.
-
- The sequences of P5CR from eubacteria (gene proC), archaebacteria and
- eukaryotes show only a moderate level of overall similarity. As a signature
- pattern, we selected the best conserved region located in the C-terminal
- section of P5CR.
-
- -Consensus pattern: [AV]-x-[LIVM]-x(7)-P-x(2)-L-x(3)-[LIVM]-[STAC](2)-x(2)-G-
- x-T-x(2)-[LIVMGA]
- -Sequences known to belong to this class detected by the pattern: ALL.
- -Other sequence(s) detected in SWISS-PROT: NONE.
- -Last update: October 1993 / Pattern and text revised.
-
- [ 1] Delauney A.J., Verma D.P.
- Mol. Gen. Genet. 221:299-305(1990).
- [ 2] Savioz A., Jeenes D.J., Kocher H.P., Haas D.
- Gene 86:107-111(1990).
-